Publications

Projects Group members Key achievements Publications

2012

Oncogenicity of the developmental transcription factor Sox9.

Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, Lopez de Munain A, Briscoe J, Serrano M, Lovell-Badge R.
Cancer Res. 2012 Jan 13. [Epub ahead of print]

PMID: 22246670

ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis.

Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA.
Gut. 2012 Jan 2. [Epub ahead of print]

PMID: 22213796

2011

Primary sclerosing cholangitis and malignancy.

Boberg KM, Lind GE.
Best Pract Res Clin Gastroenterol. 2011 Dec;25(6):753-64.

PMID: 22117640

The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer.

Sveen A, Bakken AC, Agesen TH, Lind GE, Nesbakken A, Nordgård O, Brackmann S, Rognum TO, Lothe RA, Skotheim RI.
Int J Cancer. 2011 Dec 15. doi: 10.1002/ijc.27399. [Epub ahead of print]

PMID: 22173985

FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer.

Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR.
Genes Chromosomes Cancer. 2012 Mar;51(3):240-9. doi: 10.1002/gcc.20948. Epub 2011 Nov 12.

PMID: 22081504

Endocytosis and post-endocytic sorting of connexins.

Leithe E, Sirnes S, Fykerud T, Kjenseth A, Rivedal E.
Biochim Biophys Acta. 2011 Oct 4. [Epub ahead of print]

PMID: 21996040

SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis.

Lind GE, Raiborg C, Danielsen SA, Rognum TO, Thiis-Evensen E, Hoff G, Nesbakken A, Stenmark H, Lothe RA.
Oncogene. 2011 Sep 15;30(37):3967-78.

PMID: 21499309

Phospholipase C isozymes are deregulated in colorectal cancer – insights gained from gene set enrichment analysis of the transcriptome.

Danielsen SA, Cekaite L, Agesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA.
PLoS One. 2011;6(9):e24419. Epub 2011 Sep 1.

PMID: 21909432

TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers.

Costa VL, Henrique R, Danielsen SA, Eknaes M, Patrício P, Morais A, Oliveira J, Lothe RA, Teixeira MR, Lind GE, Jerónimo C.
Epigenetics. 2011 Sep 1;6(9). [Epub ahead of print]

PMID: 21847011

Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumours.

Ahmed D, Lothe RA, Rivedal E, Lind GE.
Endocr Relat Cancer. 2011 Aug 25. [Epub ahead of print]

PMID: 21868474

Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome.

Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E.
Int J Cancer. 2011 Aug 22. doi: 10.1002/ijc.26392. [Epub ahead of print]

PMID: 21866551

Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions.

Mollerup S, Hofgaard JP, Braunstein TH, Kjenseth A, Leithe E, Rivedal E, Holstein-Rathlou NH, Nielsen MS.
Cell Commun Adhes. 2011 Aug;18(4):57-65. Epub 2011 Sep 21.

PMID: 21936631

Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.

Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA.
Mol Cancer. 2011 Jul 21;10:85.

PMID: 21777459

Cysteine-Rich Secretory Protein-3 (CRISP3) Is Strongly Up-Regulated in Prostate Carcinomas with the TMPRSS2-ERG Fusion Gene.

Ribeiro FR, Paulo P, Costa VL, Barros-Silva JD, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR.
PLoS One. 2011;6(7):e22317. Epub 2011 Jul 21.

PMID: 21814574

CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer.

Agesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI.
Genes Immun. 2011 Jun 30. doi: 10.1038/gene.2011.43. [Epub ahead of print]

PMID: 21716316

Cargo-Dependent Degradation of ESCRT-I as a Feedback Mechanism to Modulate Endosomal Sorting.

Malerød L, Pedersen NM, Sem Wegner CE, Hélène Lobert V, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H.
Traffic. 2011 Sep;12(9):1211-26.

PMID: 21564451

The testicular germ cell tumour transcriptome.

Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI.
Int J Androl. 2011 Aug;34(4 Pt 2):e133-50; discussion e150-1. doi: 10.1111/j.1365-2605.2011.01169.x. Epub 2011 Jun 9.

PMID: 21651573

MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.

Ohnstad HO, Paulsen EB, Noordhuis P, Berg M, Lothe RA, Vassilev LT, Myklebost O.
BMC Cancer. 2011 May 30;11:211:1-11. doi: 10.1186/1471-2407-11-211.

PMID: 21624110

Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival.

Sveen A, Agesen TH, Nesbakken A, Rognum TO, Lothe RA, Skotheim RI.
Genome Med. 2011 May 27;3(5):32.

PMID: 21619627

Peritoneal carcinomatosis of colon cancer origin: Highest incidence in women and in patients with right-sided tumors.

Sjo OH, Berg M, Merok MA, Kolberg M, Svindland A, Lothe RA, Nesbakken A.
J Surg Oncol. 2011 May 5. doi: 10.1002/jso.21959. [Epub ahead of print]

PMID: 21547915

A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis.

Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H.
PLoS One. 6(3):e17086.

PMID: 21474295

DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.

Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE.
Epigenetics. 2011 May;6(5):602-9. Epub 2011 May 1.

PMID: 21406965

Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma.

Berge G, Costea DE, Berg M, Rasmussen H, Grotterød I, Lothe RA, Mælandsmo GM, Flatmark K.
Amino Acids. 2011 Oct;41(4):875-84. Epub 2010 Feb 27.

PMID: 20191297

Fusion gene microarray reveals cancer type-specificity among fusion genes.

Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI.
Genes Chromosomes Cancer. 2011 May;50(5):348-57. Epub 2011 Feb 8.

PMID: 21305644

2010

DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.

Berg M, Danielsen SA, Ahlquist T, Merok MA, Ågesen TH, Vatn MH, Mala T, Sjo OH, Bakka A, Moberg I, Fetveit T, Mathisen Ø, Husby A, Sandvik O, Nesbakken A, Thiis-Evensen E, Lothe RA.
PLoS One. 2010 Nov 12;5(11):e13978.

PMID: 21103049

Molecularly Targeted Therapies for Colorectal Cancer: Strategies for Implementing Translational Research in Clinical Trials.

Zwierzina H, Bardelli A, Ciardiello F, Gariboldi M, Håkansson L, Lambrechts D, Lind GE, Loeffler-Ragg J, Schmoll H, Siena S, Tabernero J, Van Cutsem E.
Curr Opin Mol Ther. 2010 Dec;12(6):703-11.

PMID: 21154162

Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin.

Pinheiro M, Ahlquist T, Danielsen SA, Lind GE, Veiga I, Pinto C, Costa VL, Afonso L, Sousa O, Fragoso M, Santos L, Henrique R, Lopes P, Lopes C, Lothe RA, Teixeira MR.
BMC Cancer. 2010 Oct 27;10(1):587.

PMID: 20979647

Three epigenetic biomarkers, GDF15, TMEFF2 and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples.

Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jeronimo C, Lind GE.
Clin Cancer Res. 2010 Dec 1;16(23):5842-51. Epub 2010 Oct 25.

PMID: 20975101

Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes.

Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S.
Genes Chromosomes Cancer. 2010 Nov;49(11):1046-53.

PMID: 20725991

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy.

Knævelsrud H, Ahlquist T, Merok MA, Nesbakken A, Stenmark H, Lothe RA, Simonsen A.
Autophagy. 2010 Oct 1;6(7):863-70.

PMID: 20724836

Inhibition of Connexin43 gap junction channels by the endocrine disruptor ioxynil.

Leithe E, Kjenseth A, Bruun J, Sirnes S, Rivedal E.
Toxicol Appl Pharmacol. 2010 Aug 15;247(1):10-7.

PMID: 20510257

Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci.

Berg M, Agesen TH, Thiis-Evensen E, Infac IS, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA.
Mol Cancer. 2010 May 6;9(1):100.

PMID: 20459617

PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.

Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H.
Nat Cell Biol. 2010 Apr;12(4):362-71. Epub 2010 Mar 7.

PMID: 20208530

Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group.

Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA.
J Clin Oncol. 2010 Mar 20;28(9):1573-82. Epub 2010 Feb 16.

PMID: 20159821

Gap junction intercellular communication and benzene toxicity.

Rivedal E, Witz G, Leithe E.
Chem Biol Interact. 2010 Mar 19;184(1-2):229-32. Epub 2009 Nov 22.

PMID: 19932693

Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors.

Burum-Auensen E, Skotheim RI, Schjølberg AR, Røislien J, Lothe RA, Clausen OP.
J Carcinog. 2010 Mar 4;9:1.

PMID: 20411023

Regulation of gap junction intercellular communication by the ubiquitin system.

Kjenseth A, Fykerud T, Rivedal E, Leithe E.
Cell Signal. 2010 Sep;22(9):1267-73.

PMID: 20206687

Genomic aberrations in borderline ovarian tumors.

Micci F, Haugom L, Ahlquist T, Andersen HK, Abeler VM, Davidson B, Trope CG, Lothe RA, Heim S.
J Transl Med. 2010 Feb 26;8:21.

PMID: 20184781

The B[a]P-increased intercellular communication via translocation of connexin-43 into gap junctions reduces apoptosis.

Tekpli X, Rivedal E, Gorria M, Landvik NE, Rissel M, Dimanche-Boitrel MT, Baffet G, Holme JA, Lagadic-Gossmann D.
Toxicol Appl Pharmacol. 2010 Jan 15;242(2):231-40. Epub 2009 Oct 27.

PMID: 19874837

Tumor spreading to the contralateral ovary in bilateral ovarian carcinoma is a late event in clonal evolution.

Micci F, Haugom L, Ahlquist T, Abeler VM, Trope CG, Lothe RA, Heim S.
J Oncol. 2010;2010:646340. Epub 2009 Sep 15.

PMID: 19759843

2009

Functional glutathione S-transferase (GST) genotypes among testicular germ cell tumor (TGCT) survivors: associations with primary and post-chemotherapy tumor histology.

Kraggerud SM , Oldenburg J , Berg M , Alnæs GIG4, Kristensen VN, Fosså SD, Lothe RA.
Pharmacogenetics and Genomics, 2009, 19:751-759

PMID: 19741569

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.

Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E.
J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. Epub 2009 Oct 6.

PMID: 19808888

Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors.

Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA.
Neuro Oncol. 2009 Oct;11(5):514-28. Epub 2009 Jan 30.

PMID: 19182148

Large scale genomic instability as an additive prognostic marker in early prostate cancer.

Pretorius ME, Waehre H, Abeler VM, Davidson B, Vlatkovic L, Lothe RA, Giercksky KE, Danielsen HE.
Cell Oncol. 2009;31(4):251-9.

PMID: 19633362

The pluripotency transcription factor Krüppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminoma.

Godmann M, Gashaw I, Eildermann K, Schweyer S, Bergmann M, Skotheim RI, Behr R.
Mol Hum Reprod. 2009, 15:479-488

PMID: 19505997

TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours.

Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA.
Mol Cell Endocrinol, 306: 75-80, 2009.

PMID: 19041365

Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation.

Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, Lothe RA.
Hum Mutat. 2009 Jun;30(6):1023.

PMID: 18781614

Autophagy in tumour suppression and promotion.

Brech A, Ahlquist T, Lothe RA, Stenmark H.
Mol Oncol. 2009 Aug;3(4):366-75. Epub 2009 Jun 6.

PMID: 19559660

Interplay between PKC and the MAP kinase pathways in connexin43 phosphorylation and inhibition of gap junction intercellular communication.

Sirnes S, Kjenseth A, Leithe E and Rivedal E.
Biochem. Biophys. Res. Commun., 382: 41-45, 2009.

PMID: 19258009

Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours.

Bottillo I, Ahlquist T, Brekke H, Danielsen SA, van den Berg E, Mertens F, Lothe RA, Dallapiccola B.
J Pathol. 2009 Apr;217(5):693-701.

PMID: 19142971

Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map.

Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope C, Arnold N, Heim S.
Genes Chromosomes Cancer, 48:184-193, 2009.

PMID: 18973136

A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis.

Skotheim RI, Thomassen GO, Eken M, Lind GE, Micci F, Ribeiro FR, Cerveira N, Teixeira MR, Heim S, Rognes T, Lothe RA.
Mol Cancer. 2009 Jan 19;8:5.

PMID: 19152679

2008

Gene methylation profiles of normal mucosa, and benign and malignant colorectaltumors identify early onset markers.

Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA.
Mol Cancer. 2008 Dec 31;7:94.

PMID: 19117505

Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status.

Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, Lothe RA.
Hum Mutat. 2008 Nov;29(11):E252-62.

PMID: 18781614

TPD52, a candidate gene from genomic studies, is overexpressed in testicular germcell tumours.

Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA.
Mol Cell Endocrinol. 2009 Jul 10;306(1-2):75-80. Epub 2008 Nov 11.

PMID: 19041365

The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43.

Rivedal E, Leithe E.
Toxicol Appl Pharmacol. 2008 Nov 1;232(3):463-8. Epub 2008 Aug 6.

PMID: 18723040

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues.

Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, Mpindi JP, Haapa-Paananen S, Vainio P, Edgren H, Wolf M, Astola J, Nees M, Hautaniemi S, Kallioniemi O.
Genome Biol. 2008;9(9):R139. Epub 2008 Sep 19.

PMID: 18803840

The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis.

Sirnes S, Leithe E, Rivedal E.
Biochem Biophys Res Commun. 2008 Sep 5;373(4):597-601. Epub 2008 Jul 2.

PMID: 18601906

RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1,and/or RASSF1A.

Ahlquist T, Bottillo I, Danielsen SA, Meling GI, Rognum TO, Lind GE, Dallapiccola B, Lothe RA.
Neoplasia. 2008 Jul;10(7):680-6, 2 p following 686.

PMID: 18592002

The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications.

Haugen MH, Flatmark K, Mikalsen SO, Malandsmo GM.
BMC Cancer. 2008 Jun 13;8:172.

PMID: 18554396

Hypermethylated MAL gene – a silent marker of early colon tumorigenesis.

Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA.
J Transl Med. 2008 Mar 17;6:13.

PMID: 18346269

2007

Association between long-term neuro-toxicities in testicular cancer survivors andpolymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective crosssectional study.

Oldenburg J, Kraggerud SM, Brydøy M, Cvancarova M, Lothe RA, Fossa SD.
J Transl Med. 2007 Dec 27;5:70.

PMID: 18162130