Sandvig has been studying binding and intracellular transport of protein toxins from bacteria and plants. These toxins include the bacterial toxins Shiga toxin and diphtheria toxin as well as plant toxins such as abrin, ricin, modeccin and viscumin. The interactions of the toxins with cells are studied to learn more about intracellular transport in general, to investigate protein translocation across membranes, to study toxins in particular with respect to their use as cancer specific drugs, and to learn more about the intoxication process of these molecules.