Publications

2012

p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer.

Nezis IP, Stenmark H.
Antioxid Redox Signal. 2012 Jan 11. [Epub ahead of print]

PMID: 22074114

2011

Shaping development with ESCRTs.

Rusten TE, Vaccari T, Stenmark H.
Nat Cell Biol. 2011 Dec 22;14(1):38-45. doi: 10.1038/ncb2381.

PMID: 22193162

Cell differentiation: midbody remnants – junk or fate factors?

Schink KO, Stenmark H.
Curr Biol. 2011 Dec 6;21(23):R958-60. Epub 2011 Dec 5.

PMID: 22153165

Cell biology. Growth signaling from inside.

Abrahamsen H, Stenmark H.
Science. 2011 Nov 4;334(6056):611-2.

PMID: 22053037

SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis.

Lind GE, Raiborg C, Danielsen SA, Rognum TO, Thiis-Evensen E, Hoff G, Nesbakken A, Stenmark H, Lothe RA.
Oncogene. 2011 Sep 15;30(37):3967-78.

PMID: 21499309

Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome.

Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E.
Int J Cancer. 2011 Aug 22. doi: 10.1002/ijc.26392. [Epub ahead of print]

PMID: 21866551

CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.

Rønning SB, Pedersen NM, Madshus IH, Stang E.
Exp Cell Res. 2011 Aug 1;317(13):1804-16.

PMID: 21635887

Fibroblast growth factors and their receptors in cancer.

Wesche J, Haglund K, Haugsten EM.
Biochem J. 2011 Jul 15;437(2):199-213.

PMID: 21711248

Clathrin- and dynamin-independent endocytosis of FGFR3-implications for signalling.

Haugsten EM, Zakrzewska M, Brech A, Pust S, Olsnes S, Sandvig K, Wesche J.
PLoS One. 2011;6(7):e21708. Epub 2011 Jul 14.

PMID: 21779335

Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity.

Warsame AA, Aasheim HC, Nustad K, Trøen G, Tierens A, Wang V, Randen U, Dong HP, Heim S, Brech A, Delabie J.
Blood. 2011 Jul 1. [Epub ahead of print]

PMID: 21725051

Molecular mechanisms of ubiquitin-dependent membrane traffic.

Hurley JH, Stenmark H.
Annu Rev Biophys. 2011 Jun 9;40:119-42.

PMID: 21332354

Cell polarity and migration: emerging role for the endosomal sorting machinery.

Lobert VH, Stenmark H.
Physiology (Bethesda). 2011 Jun;26(3):171-80.

PMID: 21670163

Cargo-Dependent Degradation of ESCRT-I as a Feedback Mechanism to Modulate Endosomal Sorting.

Malerød L, Pedersen NM, Sem Wegner CE, Hélène Lobert V, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H.
Traffic. 2011 Sep;12(9):1211-26.

PMID: 21564451

ESCRT Proteins and Cell Signalling.

Wegner CS, Rodahl LM, Stenmark H.
Traffic. 2011 Oct;12(10):1291-7. Epub 2011 May 13.

PMID: 21518165

Endocytosis and signaling.

Platta HW, Stenmark H.
Curr Opin Cell Biol. 2011 Aug;23(4):393-403. Epub 2011 Apr 5.

PMID: 21474295

Cell biology. A helix for the final cut.

Raiborg C, Stenmark H.
Science. 2011 Mar 25;331(6024):1533-4.

PMID: 21436431

A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis.

Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H.
PLoS One. 6(3):e17086.

PMID: 21474295

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Nezis IP, Schubert DR, Simonsen A, Finley KD.
Autophagy. 2011 Jun;7(6):572-83. Epub 2011 Jun 1.

PMID: 21325881

Harald Stenmark: hands on FYVE-fingers. Interview by Caitlin Sedwick.

Stenmark H.
J Cell Biol. 2011 Feb 21;192(4):544-5.

PMID: 21339328

Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development.

Haglund K, Nezis IP, Stenmark H.
Commun Integr Biol. 2011 Jan;4(1):1-9.

PMID: 21509167

2010

Divide and ProsPer: The emerging role of PtdIns3P in cytokinesis.

Nezis IP, Sagona AP, Schink KO, Stenmark H.
Trends Cell Biol. 2010 Nov;20(11):642-9. Epub 2010 Sep 27.

PMID: 20880709

Autophagy as a trigger for cell death: Autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila.

Nezis IP, Shravage BV, Sagona AP, Johansen T, Baehrecke EH, Stenmark H.
Autophagy. 2010 Nov 16;6(8):1214-5. Epub 2010 Nov 16.

PMID: 20935512

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy.

Knævelsrud H, Ahlquist T, Merok MA, Nesbakken A, Stenmark H, Lothe RA, Simonsen A.
Autophagy. 2010 Oct 1;6(7):863-70.

PMID: 20724836

Time-resolved Ultrastructural Detection of Phosphatidylinositol 3-phosphate.

Stuffers S, Malerød L, Schink KO, Corvera S, Stenmark H, Brech A.
J Histochem Cytochem. 2010 Nov;58(11):1025-32.

PMID: 20713985

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis.

Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjørkøy G, Johansen T, Rusten TE, Brech A, Baehrecke EH, Stenmark H.
J Cell Biol. 2010 Aug 23;190(4):523-31.

PMID: 20713604

Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes.

Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H.
Dev Cell. 2010 Jul 20;19(1):148-59.

PMID: 20643357

A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

Thoresen SB, Pedersen NM, Liestøl K, Stenmark H.
Exp Cell Res. 2010 Dec 10;316(20):3368-78. Epub 2010 Jul 17.

PMID: 20643123

Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic.

Hurley JH, Stenmark H.
Annu Rev Biophys. 2010 Jul 21. [Epub ahead of print]

PMID: 21332354

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I.
EMBO J. 2010 Jul 21;29(14):2421-32.

PMID: 20551902

Protein secretion: unconventional exit by exophagy.

Abrahamsen H, Stenmark H.
Curr Biol. 2010 May 11;20(9):R415-8.

PMID: 20462486

Cytokinesis and cancer.

Sagona AP, Stenmark H.
FEBS Lett. 2010 Jun 18;584(12):2652-61.

PMID: 20371245

Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster.

Haglund K, Nezis IP, Lemus D, Grabbe C, Wesche J, Liestøl K, Dikic I, Palmer R, Stenmark H.
Curr Biol. 2010 May 25;20(10):944-50. Epub 2010 May 6.

PMID: 20451383

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.

Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A.
Mol Cell. 2010 Apr 23;38(2):265-79.

PMID: 20417604

PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.

Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H.
Nat Cell Biol. 2010 Apr;12(4):362-71. Epub 2010 Mar 7.

PMID: 20208530

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.

Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T.
Autophagy. 2010 Apr;6(3):330-44. Epub 2010 Apr 11.

PMID: 20168092

p62, an autophagy hero or culprit?

Rusten TE, Stenmark H.
Nat Cell Biol. 2010 Mar;12(3):207-9.

PMID: 20190829

ESCRT & Co.

Roxrud I, Stenmark H, Malerød L.
Biol Cell. 2010 Mar 12;102(5):293-318.

PMID: 20222872

Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5.

Wegner CS, Malerød L, Pedersen NM, Progida C, Bakke O, Stenmark H, Brech A.
Histochem Cell Biol. 2010 Jan;133(1):41-55. Epub 2009 Oct 15.

PMID: 19830447

An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy.

Groves B, Abrahamsen H, Clingan H, Frantz M, Mavor L, Bailey J, Ma D.
PLoS One. 2010 Jan 26;5(1):e8877.

PMID: 20126274

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.

Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Overvatn A, Bjørkøy G, Johansen T.
J Cell Biol. 2010 Jan 25;188(2):253-69.

PMID: 20100911

2009

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.

Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E.
J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. Epub 2009 Oct 6.

PMID: 19808888

Seeing is believing.

Stenmark H.
Nat Rev Mol Cell Biol. 2009 Sep;10(9):582.

PMID: 19702012

Rab GTPases as coordinators of vesicle traffic.

Stenmark H.
Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25. Epub 2009 Jul 15.

PMID: 19603039

Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants.

Vaccari T, Rusten TE, Menut L, Nezis IP, Brech A, Stenmark H, Bilder D.
J Cell Sci. 2009 Jul 15;122(Pt 14):2413-23.

PMID: 19571114

How do ESCRT proteins control autophagy?

Rusten TE, Stenmark H.
J Cell Sci. 2009 Jul 1;122(Pt 13):2179-83.

PMID: 19535733

SNX4 in complex with clathrin and dynein: implications for endosome movement.

Skånland SS, Wälchli S, Brech A, Sandvig K.
PLoS One. 2009 Jun 16;4(6):e5935.

PMID: 19529763

Autophagy in tumour suppression and promotion.

Brech A, Ahlquist T, Lothe RA, Stenmark H.
Mol Oncol. 2009 Aug;3(4):366-75. Epub 2009 Jun 6.

PMID: 19559660

ESCRT proteins in physiology and disease.

Stuffers S, Brech A, Stenmark H.
Exp Cell Res. 2009 May 15;315(9):1619-26. Epub 2008 Oct 28.

PMID: 19013455

Multivesicular endosome biogenesis in the absence of ESCRTs.

Stuffers S, Sem Wegner C, Stenmark H, Brech A.
Traffic. 2009 Jul;10(7):925-37. Epub 2009 Apr 10.

PMID: 19490536

Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy.

Nezis IP, Lamark T, Velentzas AD, Rusten TE, Bjørkøy G, Johansen T, Papassideri IS, Stravopodis DJ, Margaritis LH, Stenmark H, Brech A.
Autophagy. 2009 Apr;5(3):298-302. Epub 2009 Apr 19.

PMID: 19066465

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.

Raiborg C, Stenmark H.
Nature. 2009 Mar 26;458(7237):445-52.

PMID: 19325624

The role of ESCRT proteins in attenuation of cell signalling.

Rodahl LM, Stuffers S, Lobert VH, Stenmark H.
Biochem Soc Trans. 2009 Feb;37(Pt 1):137-42.

PMID: 19143618

Monitoring autophagic degradation of p62/SQSTM1.

Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T.
Methods Enzymol. 2009;452:181-97.

PMID: 19200883

Disruption of Vps4 and JNK function in Drosophila causes tumour growth.

Rodahl LM, Haglund K, Sem-Jacobsen C, Wendler F, Vincent JP, Lindmo K, Rusten TE, Stenmark H.
PLoS One. 2009;4(2):e4354. Epub 2009 Feb 4.

PMID: 19194501

ESCRTing membrane deformation.

Malerød L, Stenmark H.
Cell. 2009 Jan 9;136(1):15-7.

PMID: 19135881

2008

Guidelines for the use and interpretation of assays for monitoring autophagy inhigher eukaryotes.

Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL.
Autophagy. 2008 Feb 16;4(2):151-75. Epub 2007 Nov 21.

PMID: 18188003

Self-eating from an ER-associated cup.

Simonsen A, Stenmark H.
J Cell Biol. 2008 Aug 25;182(4):621-2.

PMID: 18725534

Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosynand Vps45.

Morrison HA, Dionne H, Rusten TE, Brech A, Fisher WW, Pfeiffer BD, Celniker SE, Stenmark H, Bilder D.
Mol Biol Cell. 2008 Oct;19(10):4167-76. Epub 2008 Aug 6.

PMID: 18685079

Membranes and organelles.

Raposo G, Stenmark H.
Curr Opin Cell Biol. 2008 Aug;20(4):357-9. Epub 2008 Jul 7.

PMID: 18588977

Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates.

Cumming RC, Simonsen A, Finley KD.
Methods Enzymol. 2008;451:639-51.

PMID: 19185743

ESCRT functions in autophagy and associated disease.

Rusten TE, Simonsen A.
Cell Cycle. 2008 May 1;7(9):1166-72.

PMID: 18418046

Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization tofacilitate polyubiquitination and degradation.

Umebayashi K, Stenmark H, Yoshimori T.
Mol Biol Cell. 2008 Aug;19(8):3454-62. Epub 2008 May 28.

PMID: 18508924

An endosomally localized isoform of Eps15 interacts with Hrs to mediatedegradation of epidermal growth factor receptor.

Roxrud I, Raiborg C, Pedersen NM, Stang E, Stenmark H.
J Cell Biol. 2008 Mar 24;180(6):1205-18.

PMID: 18362181

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.

Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, Contamine D, Rusten TE, Stenmark H, Brech A.
J Cell Biol. 2008 Mar 24;180(6):1065-71. Epub 2008 Mar 17.

PMID: 18347073

The PI 3-kinase regulator Vps15 is required for autophagic clearance of proteinaggregates.

Lindmo K, Brech A, Finley KD, Gaumer S, Contamine D, Rusten TE, Stenmark H.
Autophagy. 2008 May 16;4(4):500-6. Epub 2008 Mar 3.

PMID: 18326940

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.

Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD.
Autophagy. 2008 Feb 16;4(2):176-84.

PMID: 18059160

ESCRTing autophagic clearance of aggregating proteins.

Rusten TE, Filimonenko M, Rodahl LM, Stenmark H, Simonsen A.
Autophagy. 2008 Feb 16;4(2):233-236.

PMID: 18204305

Differential functions of Hrs and ESCRT proteins in endocytic membranetrafficking.

Raiborg C, Malerød L, Pedersen NM, Stenmark H.
Exp Cell Res. 2008 Feb 15;314(4):801-13. Epub 2007 Nov 26.

PMID: 18031739

Mechanisms and functions of endocytosis.

Miaczynska M, Stenmark H.
J Cell Biol. 2008 Jan 14;180(1):7-11.

PMID: 18195098

Cell-cycle-dependent binding kinetics for the early endosomal tethering factorEEA1.

Bergeland T, Haugen L, Landsverk OJ, Stenmark H, Bakke O.
EMBO Rep. 2008 Feb;9(2):171-8. Epub 2008 Jan 11.

PMID: 18188183

2007

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.

Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerød L, Fisher EM, Isaacs A, Brech A, Stenmark H, Simonsen A.
J Cell Biol. 2007 Nov 5;179(3):485-500.

PMID: 17984323

RILP is required for the proper morphology and function of late endosomes.

Progida C, Malerød L, Stuffers S, Brech A, Bucci C, Stenmark H.
J Cell Sci. 2007 Nov 1;120(Pt 21):3729-37.

PMID: 17959629

ESCRTs and Fab1 regulate distinct steps of autophagy.

Rusten TE, Vaccari T, Lindmo K, Rodahl LM, Nezis IP, Sem-Jacobsen C, Wendler F, Vincent JP, Brech A, Bilder D, Stenmark H.
Curr Biol. 2007 Oct 23;17(20):1817-25.

PMID: 17935992

Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila.

Simonsen A, Cumming RC, Finley KD.
Autophagy. 2007 Sep-Oct;3(5):499-501.

PMID: 17617737

Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation.

Malerød L, Stuffers S, Brech A, Stenmark H.
Traffic. 2007 Nov;8(11):1617-29.

PMID: 17714434