Publications

2012

Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling.

Hausott B, Vallant N, Hochfilzer M, Mangger S, Irschick R, Haugsten EM, Klimaschewski L.
Eur J Cell Biol. 2012 Feb;91(2):129-38. Epub 2011 Dec 9.

PMID: 22169219

2011

Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells.

Shahzidi S, Cunderlíková B, Więdłocha A, Zhen Y, Vasovič V, Nesland JM, Peng Q.
Photochem Photobiol Sci. 2011 Nov 2;10(11):1773-82.

PMID: 21881674

Fibroblast growth factors and their receptors in cancer.

Wesche J, Haglund K, Haugsten EM.
Biochem J. 2011 Jul 15;437(2):199-213.

PMID: 21711248

Clathrin- and dynamin-independent endocytosis of FGFR3-implications for signalling.

Haugsten EM, Zakrzewska M, Brech A, Pust S, Olsnes S, Sandvig K, Wesche J.
PLoS One. 2011;6(7):e21708. Epub 2011 Jul 14.

PMID: 21779335

The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein.

Jin Y, Zhen Y, Haugsten EM, Wiedlocha A.
Cell Signal. 2011 Nov;23(11):1758-66. Epub 2011 Jun 30.

PMID: 21745565

Translocation of exogenous FGF1 into cytosol and nucleus is a periodic event independent of receptor kinase activity.

Zakrzewska M, Sørensen V, Jin Y, Wiedlocha A, Olsnes S.
Exp Cell Res. 2011 Apr 15;317(7):1005-15. Epub 2011 Jan 8.

PMID: 21223966

2010

Roles of fibroblast growth factor receptors in carcinogenesis.

Haugsten EM, Wiedlocha A, Olsnes S, Wesche J.
Mol Cancer Res. 2010 Nov;8(11):1439-52.

PMID: 21047773

Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes.

Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H.
Dev Cell. 2010 Jul 20;19(1):148-59.

PMID: 20643357

Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster.

Haglund K, Nezis IP, Lemus D, Grabbe C, Wesche J, Liestøl K, Dikic I, Palmer R, Stenmark H.
Curr Biol. 2010 May 25;20(10):944-50. Epub 2010 May 6.

PMID: 20451383

Sialic acid-binding dwarf elder four-chain lectin displays nucleic acid N-glycosidase activity.

Iglesias R, Citores L, Ferreras JM, Pérez Y, Jiménez P, Gayoso MJ, Olsnes S, Tamburino R, Di Maro A, Parente A, Girbés T.
Biochimie. 2010 Jan;92(1):71-80. Epub 2009 Sep 30.

PMID: 19799962

2009

Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane.

Zakrzewska M, Zhen Y, Wiedlocha A, Olsnes S, Wesche J.
Biochemistry. 2009 Aug 4;48(30):7209-18.

PMID: 19558187

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.

Zakrzewska M, Wiedlocha A, Szlachcic A, Krowarsch D, Otlewski J, Olsnes S.
J Biol Chem. 2009 Sep 11;284(37):25388-403. Epub 2009 Jul 2.

PMID: 19574212

Endocytosis and intracellular transport of FGF1 and the FGF receptors.

Haugsten EM.
Norsk Farmaceutisk Tidsskrift, 6/2009, 21-22. (in Norwegian)

Link to article in NFT

Structure of a highly stable mutant of human fibroblast growth factor 1.

Szlachcic A, Zakrzewska M, Krowarsch D, Os V, Helland R, Smalås AO, Otlewski J.
Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):67-73. Epub 2008 Dec 18.

PMID: 19153468

2008

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.

Haugsten EM, Malecki J, Bjørklund SM, Olsnes S, Wesche J.
Mol Biol Cell. 2008 Aug;19(8):3390-403. Epub 2008 May 14.

PMID: 18480409

FGF-1: from biology through engineering to potential medical applications.

Zakrzewska M, Marcinkowska E, Wiedlocha A.
Crit Rev Clin Lab Sci. 2008;45(1):91-135.

PMID: 18293181

Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.

Sørensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T, Olsnes S, Wiedlocha A.
Mol Cell Biol. 2008 Jun;28(12):4129-41. Epub 2008 Apr 14.

PMID: 18411303

2007

Indirubin-3′-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK.

Zhen Y, Sørensen V, Jin Y, Suo Z, Wiedłocha A.
Oncogene. 2007 Sep 27;26(44):6372-85.

PMID: 17533378

A nuclear export sequence located on a beta-strand in fibroblast growth factor-1.

Nilsen T, Rosendal KR, Sørensen V, Wesche J, Olsnes S, Wiedłocha A.
J Biol Chem. 2007 Sep 7;282(36):26245-56.

PMID: 17616529